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There are several genetic strains of HBV (genotypes A-H), which vary in geographic distribution, response to treatment, and risk of progression to advanced liver disease (Liaw 2009

Carrero, J

NAD+ is a coenzyme required for glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation

522 The contributions of the other UPR arms to lipid homeostasis have also been described, including protective effects of both the PERK/eIF2 and ATF6 branches against hepatosteatosis in ER-stressed mice and an ATF6-mediated upregulation of fatty acid oxidation and downregulation of lipogenesis in hepatocytes

Mehlman, and T