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A separate clinical trial investigating whether a 30-day probiotic supplementation (1 10 9 CFU/day) could reduce the incidence of diarrhea in HIV patients concluded that extending the treatment duration beyond one month may be necessary to elicit measurable clinical benefits (507)

Methane alleviates inflammation and apoptosis of dextran sulfate sodium-induced inflammatory bowel diseases by inhibiting toll-like receptor 4 (TLR4)/Myeloid differentiation factor 88 (MyD88)/Nuclear translocation of nuclear factor-b (NF-B) and endoplasmic reticulum stress pathways in mice

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Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis