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Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis

Peynshaert, S.C

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3.3 FGF2 downregulates reactive oxygen species in 5% O 2, increasing redox-sensitive PDH activity We previously reported that culturing hPSCs at 5% O 2 reduces levels of ROSkey second messengers known to modulate FGF2 signalingand that FGF2 signaling likely contributes to ROS suppression in 5% O 2 , as MEK1/2 inhibition led to increased ROS levels under 5% but not 21% O 2 ( 2 (Figure 3A)

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