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It can be observed that although the STS administration protocols vary across studies, they consistently demonstrate therapeutic benefits and a relatively favourable safety profile [5153]

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Mild symptoms may improve with conservative care, especially if constipation or straining is the main trigger

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The oxidative stress agents produced by IAA have the potential to inflict damage on DNA, resulting in compromised cellular function and potentially leading to cell death (Marchetti et al., 2006)

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Furthermore, combination of topical and oral glutathione might be superior to monotherapy

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doi: 10.1021/j100319a004

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