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It can be observed that although the STS administration protocols vary across studies, they consistently demonstrate therapeutic benefits and a relatively favourable safety profile [5153]

Mild symptoms may improve with conservative care, especially if constipation or straining is the main trigger

The oxidative stress agents produced by IAA have the potential to inflict damage on DNA, resulting in compromised cellular function and potentially leading to cell death (Marchetti et al., 2006)

Furthermore, combination of topical and oral glutathione might be superior to monotherapy

doi: 10.1021/j100319a004
