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Two are FDA-approved specifically as injectable weight loss medications: Saxenda (liraglutide) approved in 2014, injected once daily

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When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects