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They reemerged hepatocyte growth factor receptor (MET) signaling in LPS-induced CVX-BMDMs/RAW 264.7 cells, followed by activating downstream Ras pathway, which promoted the retrograde transfer of Arg-2 from mitochondria into the cytoplasm and remodeled energy/arginine metabolism by enhancing OXPHOS to mobilize M2 phenotype for improving rat osteoporotic bone defect (demonstrated by flow cytometry, IF, ELISA, and RT-qPCR) (Fig

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