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(1990) proposed that APAP consumption may have depleted GSH stores, which causes accumulation of pyroglutamic acid

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NAC treatment significantly improved BMI, waist circumference and waist-to-hip ratio, while metformin did not

References Abdelhamid AS, et al

These findings should be viewed as hypothesis-generating , providing a systems-level context for the observed metabolite changes rather than evidence of causal normalization