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Description
Novo Nordisk developed it as a long-acting version of the naturally occurring hormone, engineered with specific amino acid substitutions that extend its duration of action from minutes to days

J Cardiothorac Vasc Anesth 22(4):584-6, 2008

doi: 10.1007/s00380-005-0854-4

Hits the immune system from multiple angles

Pierini, Reto Brun, Mara R
