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These findings suggest partialbut incomplete-cell compensation and support the concept of a relatively more insulin-resistant metabolic milieu during the luteal phase

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Other medicines warranting caution include: Oral contraceptives the tirzepatide SmPC (Mounjaro, MHRA/emc) notes a reduction in oral contraceptive exposure during initiation and dose escalation, and advises considering additional contraceptive precautions during this period
