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It is particularly prevalent among women in their 40s and 50s because the transition into menopause involves a significant decline in estrogen
Remember also that the FDA doesn't test or regulate supplements the same way they do with medicines

doi: 10.1111/ejn.12968 49 KavanaghE

Recent systematic reviews and meta-analyses suggest that platelet rich plasma injections outperform corticosteroids, viscosupplementation, and placebo when it comes to symptomatic knee osteoarthritis