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Conclusions and Future Directions One-carbon metabolism is essential for cellular function and relies on B vitamins to drive and coordinate the generation of methyl groups for a myriad of biological outcomes

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Increased Receptor Affinity (Hypothesized): Some research suggests that the lack of the N-terminal tripeptide actually enhances its binding affinity to the IGF-1R in damaged or targeted cells, leading to a strong, immediate growth signal that promotes satellite cell recruitment, repair, and growth

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