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Schemann and colleagues (663) recently reviewed this topic in the context of the ENS, asking: How smart is the gut

If you have been taking oral B12 supplements without feeling any improvement, this may be why

Abbreviations (SNC-80): ((+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N, N-diethyl-benzamide) (CFA): complete Freund's adjuvant (DAMGO): [D-Ala(2), N-Me-Phe(4), Gly(5)-ol]-enkephalin (DORs): delta opioid receptors (DRG): dorsal root ganglion (ERK1/2): extracellular signalregulated kinases (GASP): G protein coupled receptor associated sorting protein (GIRK): G protein activated inward rectifier K+ (GPCRs): G protein-coupled receptors (LC): locus coeruleus (MORs): mu opioid receptors (AR-M1000390): N, NDiethyl- 4-(phenylpiperidin-4-ylidenemethyl) benzamide

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Investigators also collected serial blood samples to track shifts in lipids, C-reactive protein, and liver enzymes, providing a broader picture of metabolic health