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While it showed anti-obesity signal and advanced into clinical trials, it failed to show sufficient weight-loss effects to support commercialization. AOD-9604 vs HGH Fragment 176191: Whats the Difference

2007;(4):CD003620
Nutrients 16:2343

Small molecules below 75100 Da can readily permeate the mucosa, whereas permeability decreases sharply as molecular size increases, making most therapeutic peptides poorly absorbed via this route without incorporating any additives
Pros: Interesting early human data
