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Similar to LCC ICCG , DmPETase could also efficiently degrade amorphous PET, releasing substantial water-soluble products (119 g/mg PET for DmPETase and 414 g/mg PET for LCC ICCG )

AP: Formal analysis, Writing review & editing, Validation, Data curation, Software, Supervision, Conceptualization

Among the environmental factors involved in the pathogenesis of ASD, prenatal exposure to the antiepileptic drug valproic acid (VPA) has been repeatedly associated with increased risk of neurodevelopmental delay and autistic symptoms in the offspring ( Although the mechanisms by which VPA interferes with development causing autistic-like features in the exposed offspring need to be still elucidated, an imbalance between GABAergic and glutamatergic neurotransmission has been reported, which is also implicated in ASD etiology ( Increased oxidative stress has been identified as a possible mechanism through which environmental factors exert their deleterious effects on the developing brain ( N-acetylcysteine (NAC) is a synthetic derivative of the endogenous amino acid L-cysteine that is able to modulate glutamatergic neurotransmission and the excitatory/inhibitory ratio ( The antioxidant properties of NAC and its ability to modulate glutamatergic neurotransmitters have prompted studies focused on the potential clinical application of NAC in ASD ( Here, we explored the impact of repeated administration of NAC on core autistic-like features (such as social impairments and stereotyped behaviors) in the VPA rat model of ASD

And, and help them, you know, put a lunch pail in their backpack and send em [00:11:00] off to school

The role of the extracellular matrix components in cutaneous wound healing