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The biological function of this localized radical flux is critically shaped by SOD1 and SOD2, which catalyze the dismutation of O 2 to H 2 O 2 within microseconds

It can be induced to undergo endoplasmic reticulum stress in response to inflammation, oxidative stress, and hypoxia, thereby regulating intracellular environmental homeostasis through unfolded protein responses

22,23 In patients with a normal or low-normal serum vitamin B 12 level, complete blood count results demonstrating macrocytosis, or suspected clinical manifestations, a serum methylmalonic acid level is an appropriate next step 1,2,6,18 and is a more direct measure of vitamin B 12 's physiologic activity

10.1111/j.1476-5381.2011.01238.x Br

Dotti CG, Sullivan CA, Banker GA