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We summarize potential use by injury mechanism, therapeutic timing, route of administration, monitoring strategy, safety considerations, and evidence level

Cancer Cell 21 , 105120 (2012)

Glutathione deficiency may be caused by aging, by inadequate dietary intake of the sulfur-containing amino acid cysteine, or by exposure to damaging substances such as mycotoxins, drugs, alcohol and environmental pollutants

doi: 10.1016/j.pdpdt.2017.07.010

To synthesize these elements into a practical tool, Figure 5 summarizes a stepwise PKPD algorithm that starts from genotype-inferred metabolic capacity, explicitly accounts for phenoconversion, incorporates secondary pharmacodynamic markers, and uses TDM for continuous phenotype reassessment during antidepressant management