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The major caveats for the clinician to recognize are that HLA allele associations are currently known for a limited number of drugs, there is a wide range in quality of data supporting HLA allele associations, prevalence of at risk HLA alleles can vary greatly amongst different populations so may not be applicable to the providers patient/population, and the positive and negative predictive values (PPV and NPV) of having predisposing HLA alleles are highly variable