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p53 has also been described as a key player in the induction of senescence since, in concert with PI3K/AKT/mTOR signaling, it can drive the cells to an irreversible cell cycle arrest that counteracts oncogenic transformation [82]

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Reynolds created a Medical Relations Division (MRD) in the early 1940s that became the base of their aggressive physician/health claims promotional strategy

Used in low doses like those delivered by combustible cigarettes, stimulants activate the nervous system, resulting in enhanced arousal and alertness

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