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Flumazenil, a specific benzodiazepine receptor antagonist indicated for the complete or partial reversal of the sedative effects of benzodiazepines in the management of benzodiazepine overdosage, can lead to withdrawal and adverse reactions, including seizures, particularly in the context of mixed overdosage with drugs that increase seizure risk (e.g., tricyclic and tetracyclic antidepressants) and in patients with long-term benzodiazepine use and physical dependency

The mechanism of hair damage is directly related to the impact of tobacco smoke on the microcirculatory bed of hair follicles: Genotoxic effect on the DNA of hair follicles

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In 2013, Imperial Brands acquired the Ruyan brand and all its intellectual property rights

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