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For the most part, the discrepancies in results have been ascribed to the methodological differences (per-analytical and analytical issues), and/or biological variables ( e.g

Nicotine, a component of tobacco found in cigarettes, cigars, and e-cigarettes, is a highly addictive substance which contributes to compulsive use, relapse after abstinence, and physical dependence
the study's authors say it will take 10 to 15 years to notice them in chronic users

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