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2016 Oct;36(5):496-9
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[56] Continuous exposure to nicotine can cause an increase in the number of nicotinic receptors, which is believed to be a result of receptor desensitization and subsequent receptor upregulation
Pesticides including organochlorines (e.g., DDT) and other persistent organic pollutants are used in tobacco cultivation, especially in low- and middle-income countries
Using a lower-powered device or a 50/50 VG/PG mix can reduce vapor output and lower risk
