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Although there is not enough evidence to support the use of one particular salt over the other to treat a specific disorders, these preferences by prescribers follow the notion that hydroxyzine Pamoates lipid solubility allows the drug to readily cross the blood-brain barrier and treat disorders of the brain and the central nervous system, while what soluble Hydroxyzine hydrochloride will not easily cross the blood-brain barrier, as such, will better serve as an antihistamine

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