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There are reports of the pods leaking at high altitudes so having them in a sealed bag is highly recommended

By restricting the analyses to a sample of young adults with no history of respiratory disease or wheezing symptom, the study mitigated potential bias that patterns of use and exposure may have influenced by pre-existing respiratory conditions. The study also found that tobacco flavored e-cigarette users had 170 percent greater odds of developing any respiratory symptom compared to never users

PLoS ONE 19 , e0302816 (2024)

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Fill capacity means the normal amount the container is designed to hold during real use, allowing room for the cap, lid, pump, seal, or normal product movement