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Regular users of the drug will find both have a similar effect

Nine companies responded in writing

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Some of the effects of nicotine may be traced to its many receptors in cholinergic binding sites in the brain

Physiol Rev 89:73120 Almeida OP, Garrido GJ, Lautenschlager NT, Hulse GK, Jamrozik K, Flicker L (2008) Smoking is associated with reduced cortical regional gray matter density in brain regions associated with incipient Alzheimer disease
