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The filler, wrapper and binder were grown at Fernandez family farms in Nicaragua and aged three to five years

A Report of the Surgeon General (US Department of Health and Human Services, Washington DC, 1982)

Rather than taxing by the volume of fluid, Kentucky and New Mexico tax by the cartridge at $1.50 and $0.50 per cartridge respectively

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Other metabolites of interest that were associated with at least one of the tobacco exposure biomarkers and one of the early birth outcomes were ophthalmate, 3,4-dihydroxyphenylalanine (L-DOPA), dihomo-gamma-linolenic acid (DGLA), 3-hydroxydodecanoyl carnitine, and glutamine