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Once in the brain, nicotine binds to nicotinic acetylcholine receptors leading to the release of multiple neurotransmitters (dopamine, norepinephrine, serotonin, gamma aminobutyric acid (GABA), glutamate and endorphins) in the central nervous system.53 Dopamine is the predominant neurotransmitter released, and it is associated with pleasure and appetite suppression

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In 1975, the shareholding had increased to 100%

Maeda, Y., Dave, V

A follow-up study showed that IQOS exposure did not affect heart weight, left ventricular structure, atherosclerosis progression, heart function, and gene expression related to atherosclerosis and cardiovascular diseases 76