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Haglid at Kungliga Tekniska Hgskolan (KTH, Royal Institute of Technology) and collaborators conducted a broad synthesis-based search for nicotine analogue compounds that exhibit significant agonistic activity at nicotinic acetylcholine receptors (nAChRs)
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While early tobacco cultivation techniques were relatively rudimentary, colonial farmers quickly developed more efficient techniques
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This in turn created a tremendous demand for slaves
