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Nicotine, although not directly mutagenic, promotes tumor progression by activating nicotinic acetylcholine receptors (nAChRs) and -adrenergic receptors on gastric cells

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Evidence for an association between price increases in ENDS and higher demand for cigarettes has support in prevalence/frequency studies, but the effect did not reach statistical significance in a meta-analysis of sales/purchases studies, likely because the much smaller ENDS market is limited in its effects on the larger cigarette market

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