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And for good reason: they make a product that kills over 1,200 people a day, so someone needs to say something

Notably, cigarette smoke exposure induces pronounced and selective upregulation of GPR15 expression in colonic immune cells, whereas epithelial compartments exhibit minimal changes, underscoring a cell type-specific regulatory pattern (Supplementary Fig

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Prolonged use intensifies the long-term effects on the mucosa, causing frequent nasal congestion and making it more susceptible to inflammation

Our results are in broad agreement with previous findings