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tobacco use became popular in european culture History of the World — Tobacco Timeline Mapped: Europe's Tobacco Use By
Description
Moreover, by the end of the XIX century nicotines empirical formula was described (1843, Louis-Henri-Frederic Melsens), the structure was discovered (1893, Adolf Pinner) and in 1904 pure nicotine was first synthesized by a Swiss Ame Pictet

Electronic nicotine delivery systems or E cigarettes do not burn tobacco but instead vaporise nicotine solution and hence equally dangerous
[DOI] [PMC free article] [PubMed] [Google Scholar] Dent J., Holloway R

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