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It can also increase the side effects of caffeine and exacerbate the symptoms of conditions like heart disease when combined with certain medications

Since the tobacco tax increase in 2010 and the earthquake in 2011, which damaged the production facility of Japan Tobacco, cigarette smokers started to explore other products, such as RYO tobacco, as an alternative
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Sugars are added for flavour and humidifiers ensure that the tobacco does not dry out
