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For this tobacco harm reduction approach to succeed in efficiently reducing harm compared with continued conventional cigarette smoking, two criteria must be fulfilled by these non-combustible nicotine-containing next-generation products (NGPs): 1

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To address multiple comparisons, false discovery rate (FDR) adjustment using the Benjamini-Hochberg procedure was applied to the bivariable p -values

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Fermentation : Post-curing, the leaves are fermented