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"RAI is committed to promoting tobacco harm reduction, in other words, identifying consumer-acceptable tobacco products that may present less harm than conventional tobacco-burning cigarettes." Altria, which owns Philip Morris USA, the maker of Marlboro cigarettes, said in a separate emailed statement that the company "will carefully review the proposed rule and its implications to our businesses and submit comments." More than 40 million adults in the United States still smoke cigarettes, according to the CDC, and about 4.7 million middle and high school students use at least one type of tobacco product, including e-cigarettes.

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Based on changes in smoking habits in the health screening examination data, smokers were categorized into three groups: quitters, reducers, and sustainers