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Investigations for a very short time period in canine models and long-term cannulated mice exposed to concentrated air particles showed that hypertension was produced and that there was an indication of central sympathetic activation of the neuron system, presumably induced by neuro-inflammation in relation to the disclosure of PM 2.5 (190, 191)

An 1891 WHC morta bulldog The other (shown above) is an uncased 1891 bulldog, also with WHC Chester hallmarks, but its unknown where it was sold

Supplementary material The Supplementary Material for this article can be found online at: References 1 Global Burden of Disease Collaborative Network