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Thus, while prior smoke exposure promotes increased inflammation and impairs the immune response, P6 immunization mitigated the negative impact of cigarette smoke exposure on bacterial clearance, lung inflammation and the adaptive immune response

Du, Yu Chen, Shuai Deng, Chihin Cho, Qianxiu Li, Xiaobing Li, Wanping Li, Fang Wang, Yuhong Sun, Li Gu, Meijuan Chen, Mingxing Li Journal: Environmental pollution Journal ranking: Q1 Key takeaways: Cigarette smoking promotes inflammation and cancer by affecting immune cells and influencing molecular mechanisms, including epigenetics and DNA damage

This implies a mechanistic link between smoke exposure mediated HBE cell necrosis and the chronic inflammation associated with airway remodeling

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It results from bacteria or fungi entering through a crack or cut in the skin