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In Addiction (29 January 2018), researchers carried out a meta-analysis of 61 studies involving 27,647 participants who were randomly assigned to either an intervention group, which received smoking cessation medicines including bupropion, varenicline and nicotine replacement []

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Conducted by Franzen et al., the study results were obtained by monitoring participants vitals during and after they had smoked a cigarette, or vaped a nicotine containing or non-nicotine containing e-cigarette