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20 Other neurotransmitters that may be involved in nicotine addiction are the hypocretins, neuropeptides produced in the lateral hypothalamus that regulate the stimulatory effects of nicotine on reward centers in the brain and modulate self-administration of nicotine in rodents

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Moreover, using an isolated vagus nerve preparation, we investigated the ability of nicotine to induce membrane depolarisation, which is a measure of sensory nerve activation

Harrigan, J