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Overall, the interaction risk between sedatives and cannabis is high

Am J Addict 25:210214 Ballester LY, Capo-Velez CM, Garcia-Beltran WF, Ramos FM, Vazquez-Rosa E, Rios R, Mercado JR, Melendez RI, Lasalde-Dominicci JA (2012) Up-regulation of the neuronal nicotinic receptor alpha7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder
