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Damage to the lungs and a decline in lung function are directly proportional to the number of packs of cigarettes smoked per day multiplied by the number of years smoked, a metric known as pack years. The longer years in the pack, the more probable the lungs may be permanently damaged

Jeremy was on the spectrum

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In rare cases, extremely high doses of THC can lead to more severe symptoms, though it's important to remember these are uncommon

(2011) report that 20 h after 4 daily doses of a large dose of tranylcypromine (3 mg/kg) nicotine self-administration is not increased though MAO is still inhibited, Smith et al