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doi: 10.3389/fnut.2025.1686056 Received 14 August 2025 Accepted 25 September 2025 Published 16 October 2025 Volume 12 - 2025 Edited by Mingyue Song, South China Agricultural University, China Reviewed by Ludovica Verde, University of Naples Federico II, Italy Arely Vergara-Castaeda, La Salle University of Northwest, Mexico Updates Copyright 2025 Chyliska and Maciejczyk

Riyi Shi 1,2 1 Department of Basic Medical Sciences, College of Veterinary Medicine, 2 Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN Corresponding author: Riyi Shi, 765-496-3018, [email protected] Acrolein, an ,-unsaturated aldehyde associated with oxidative stress, is also a major toxic component of tobacco cigarette smoke, which has been reported in the clinic to coincide with the exacerbation of neuropathic pain after SCI