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Regular and heavy cannabis use, especially in susceptible individuals, has been associated with an increased risk of developing mental health disorders such as anxiety, depression, and psychosis
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rather, MAO inhibition needs to be more chronic, persisting for a week or more (Smith et al., 2015, 2016), which means that the effect of MAO inhibition of nicotine self-administration is not a direct effect of MAO inhibition per se , but additionally requires some chronic adaptation to MAO inhibition
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