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However, filters do not appear to have a beneficial effect on smoking-related mortality [1214], and may have played a role in the shift of lung cancer incidence from peripheral squamous cell carcinoma to central adenocarcinoma [1417]

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Electronic cigarettes (e-cigarettes) and HNBC were initially developed to support the cessation of tobacco smoking, offering a less harmful alternative to traditional cigarettes

Despite this imperfection, the critical finding is clear: a sharp discontinuity appears at 1989 the real treatment date where the effect approximately doubles from -8.4 (1988) to -14.1 (1989) and continues deepening thereafter