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Human twin studies and animal research demonstrate that these genes significantly influence smoking behavior, nicotine dependence, and quit success by controlling how nicotine interacts with the brains reward system, particularly in the dopaminergic cells of the ventral tegmental area and nucleus accumbens These genetic factors make certain people more likely to develop tobacco dependence compared to others

Henriksen is a contractor for the California Tobacco Control Program and has consulted for the US Food and Drug Administrations Center for Tobacco Products

Nicotine, a powerful insect neurotoxin, is one of many chemicals produced by tobacco that evolved to deter pests

Cobb argues that Crick made fundamental contributions to neuroscience while in California
doi: 10.1016/j.schres.2016.01.020
