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Despite its growing popularity, the Food and Drug Administration (FDA) warns consumers not to use kratom because of its potential for serious adverse health events including liver toxicity, seizures and substance use disorder

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The US Department of Health and Human Services guideline meta-analysis suggests that bupropion SR plus nicotine patch increase long term tobacco abstinence rates compared with nicotine patch alone with odds ratio (OR) 1.3 (95% CI 1 to 1.8) [42]

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