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nonetheless, the presence of nicotine could somehow perpetuate platelet functional changes in a dose-dependent manner, making its role in electronic cigarette-induced damage even more inconclusive.81 Another link to cellular dysfunction induced by vaping was provided by a study analysing the response of liver Kupffer cells both to classic and electronic cigarette extracts exposure

Characteristically, the lesion shows multiple rugae-like folds and deep clefts between them

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