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* 95% less represents the average reductions in levels of a range of harmful chemicals (excluding nicotine) compared to the smoke of a reference cigarette (3RF4F).
doi: 10.1016/S0893-133X(02)00295-6 30 ODellLEBruijnzeelAWSmithRTParsonsLHMervesMLGoldbergerBAet al

Although this determination may affect the precision of the numbers we present, there is sufficient evidence in total to support our findings and conclusions for UC

Nicotine stimulates catecholamine release , intensifying norepinephrines constrictive action on vascular smooth muscle

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