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"This increase was blunted and even partially reversed in patients who are habitual e-cigarette smokers." Researchers added that blood flow to the heart was reduced at rest, even in the absence of stress, after a puff on an e-cigarette

Conversely, two mast cell lines do express CB1 and CB2 at both the mRNA and protein level [105] and another study detected CB2 mRNA in rat peritoneal mast cells although administration of 9 -THC dose-dependently released histamine irrespective of the CBRs [106]