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Ive had patients who became depressed after quitting, Dr

Substance Abuse and Mental Health Services Administration

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Reducing adolescent tobacco use will require comprehensive tobacco control policies that are applied equally to and inclusive of all tobacco products, including chewing tobacco and cigars

27 Studies measuring biomarkers of the dangerous substances in tobacco smoke (see Section 12.5.6) find that, compared to quitting completely, smokers who cut down still have relatively high levels of biomarkers of oxidative stress (an imbalance of free radicals and antioxidants in the body) such as glutathione 28 and other metabolites such as thiocyanate, 29 TNE-2, NNAL, NNN, 2-Fluorene, HPMA, CYMA, and MHB3