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Thats not a gray area
Again, according to Table 1, when quitting is defined as ending the use of all tobacco products, including e-cigs, unassisted quitting was twice as effective at helping smokers arrest their dependence upon nicotine after 12+ months
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J Med Chem 47 , 57135720 (2004)
A 2010 study in the Lancet by the former UK chief drugs adviser David Nutt asked drug-harm researchers in Britain to score various drugs by a range of harmful effects such as drug-related mortality, crime, drug dependency, and economic costs
