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Nicotine is a minor player with respect to smoking-induced cardiovascular disease, says Benowitz

Am J Respir Cell Mol Biol 2 , 9198, doi:10.1165/ajrcmb/2.1.91 (1990)

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How smoking during pregnancy can affect your baby Smoking during pregnancy can increase the risk of premature birth, birth defects (e.g
Free radicals are molecules with unpaired electrons, an inevitable byproduct of the bodys many biochemical processes and, when in disproportionately large supply, a contributor to disease and dysfunction
